Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy. (8th June 2018)

• Record Type: Journal Article
• Authors: Wang, Yimin; Cuzzucoli, Fabio; Escobar, Andres; Lu, Siming; Liang, Liguo; Wang, ShuQi
• Is Part Of: Nanotechnology. Volume 29:Number 33(2018)
• Publication Date: 2018-06-08
• Subjects: tumor-on-a-chip -- nanoparticles -- cancer therapy; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/aac7a4
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Cancer has become the most prevalent cause of deaths, placing a huge economic and healthcare burden worldwide. Nanoparticles (NPs), as a key component of nanomedicine, provide alternative options for promoting the efficacy of cancer therapy. Current conventional cancer models have limitations in predicting the effects of various cancer treatments. To overcome these limitations, biomimetic and novel 'tumor-on-a-chip' platforms have emerged with other innovative biomedical engineering methods that enable the evaluation of NP-based cancer therapy. In this review, we first describe cancer models for evaluation of NP-based cancer therapy techniques, and then present the latest advances in 'tumor-on-a-chip' platforms that can potentially facilitate clinical translation of NP-based cancer therapies.