Rotating lamellipodium waves in polarizing cells. Issue 1 (December 2018)

• Record Type: Journal Article
• Authors: Reeves, Cody; Winkler, Benjamin; Ziebert, Falko; Aranson, Igor
• Is Part Of: Communications physics. Volume 1:Issue 1(2018)
• Page Start: 1
• Page End: 11
• Publication Date: 2018-12
• Subjects: Physics -- Periodicals; 530
• DOI: 10.1038/s42005-018-0075-7
• Languages: English
• ISSNs: 2399-3650

Abstract

Abstract Cellular protrusion- and lamellipodium waves are widespread for both non-motile and moving cells and observed for many cell types. They are involved in the cell's exploration of the substrate, its internal organization, as well as for the establishment of self-polarization prior to the onset of motion. Here we apply the recently developed phase field approach to model shape waves and their competition on the level of a whole cell, including all main physical effects (acto-myosin, cell membrane, adhesion formation and substrate deformation via traction) but ignoring specific biochemistry and regulation. We derive an analytic description of the emergence of a single wave deformation, which is of Burgers/Fisher-Kolmogorov type. Finally, we develop an amplitude equation approach to study multiple competing rotational waves and show how they allow the cell to transition from a non-moving state towards a polarized, steady moving state. Lamellipodial waves are a very general phenomenon observed in many cell types and is a typical phenomenon for animal cells to adhere and move along substrates. The authors present a model showing that the dynamics of these waves can be reproduced with a minimal, well-defined set of parameters.