Enhanced dissolution of valsartan-vanillin binary co-amorphous system loaded in mesoporous silica particles. (2nd January 2019)

• Record Type: Journal Article
• Authors: Hashim Ali, Khan; Mohsin Ansari, Muhammad; Ali Shah, Fawad; Ud Din, Fakhar; Abdul Basit, Muhammad; Kim, Jin-Ki; Zeb, Alam
• Is Part Of: Journal of microencapsulation. Volume 36:Number 1(2019)
• Page Start: 10
• Page End: 20
• Publication Date: 2019-01-02
• Subjects: Valsartan -- vanillin -- co-amorphous system -- mesoporous silica particles -- dissolution; Microencapsulation -- Periodicals; Controlled release technology -- Periodicals; 615.19
• DOI: 10.1080/02652048.2019.1579265
• Languages: English
• ISSNs: 0265-2048

Abstract

Abstract: The study was aimed to prepare a co-amorphous system of valsartan (VAL) with vanillin (VAN) for improving its solubility and dissolution followed by its confinement in mesoporous silica particles (MSPs) to stabilise the co-amorphous system and prevent its recrystallization. Amorphous VAL and VAN were obtained through quench-cooling and VAL/VAN binary co-amorphous system (VAL/VAN-CAS) was prepared through solvent evaporation technique. The particle size and morphology of VAL/VAN-CAS-MSPs were studied using scanning electron microscopy (SEM) and solid-state characterisation was performed by differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). The in vitro dissolution was investigated by dialysis bag diffusion method. SEM analysis revealed irregular shaped VAL/VAN-CAS-MSPs with a size range of 5–25 μm, while outcomes of DSC and XRPD confirmed the formation of VAL/VAN-CAS. The in vitro dissolution profiles demonstrated a significantly increased dissolution in first 60 minutes from VAL/VAN-CAS (∼68%) and VAL/VAN-CAS-MSPs (∼76%) compared to powder VAL (∼25%).