Evaluation of biofouling in stainless microfluidic channels for implantable multilayered dialysis device. (17th May 2017)

• Record Type: Journal Article
• Authors: Ota, Takashi; To, Naoya; Kanno, Yoshihiko; Miki, Norihisa
• Is Part Of: Japanese journal of applied physics. Volume 56:Number 6(2017)Supplement 1
• Publication Date: 2017-05-17
• Subjects: Physics -- Periodicals; 621.05
• DOI: 10.7567/JJAP.56.06GN10
• Languages: English
• ISSNs: 0021-4922

Abstract

Abstract: An implantable artificial kidney can markedly improve the quality of life of renal disease patients. Our group has developed an implantable multilayered dialysis system consisting of microfluidic channels and dialysis membranes. Long-term evaluation is necessary for implant devices where biofouling is a critical factor, culminating in the deterioration of dialysis performance. Our previous work revealed that surface conditions, which depend on the manufacturing process, determine the amount of biofouling, and that electrolytic etching is the most suitable technique for forming a channel wall free of biofouling. In this study, we investigated the electrolytic etching conditions in detail. We conducted in vitro experiments for 7 d and evaluated the adhesion of biomaterials by scanning electron microscopy. The experiments revealed that a surface mirror-finished by electrolytic etching effectively prevents biofouling.