Beyond rehabilitation in MS: Insights from non-invasive brain stimulation. (September 2019)

• Record Type: Journal Article
• Authors: Leocani, Letizia; Chieffo, Raffaella; Gentile, Antonietta; Centonze, Diego
• Other Names: Feys Peter guest-editor.; Sastre-Garriga Jaume guest-editor.
• Is Part Of: Multiple sclerosis. Volume 25:Number 10(2019)
• Page Start: 1363
• Page End: 1371
• Publication Date: 2019-09
• Subjects: Synaptic plasticity -- neuromodulation -- experimental autoimmune encephalomyelitis (EAE) -- transcranial magnetic stimulation -- transcranial direct current stimulation; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458519865734
• Languages: English
• ISSNs: 1352-4585

Abstract

Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful approach targeting central nervous system plasticity. Another driver of brain plasticity is non-invasive brain stimulation (NIBS), receiving recent attention in neurology, particularly for its potential synergy with neurorehabilitation and as add-on treatment for several neurological conditions, from pain to fatigue to sensorimotor and cognitive deficits. In this review, we will resume the evidence exploring the neurobiological basis of NIBS and its applications to MS-related conditions.