Comparing the effects of Triptorelin and Calendula officinalis on size and pathology of induced endometriosis in rats. Issue 3 (September 2019)

• Record Type: Journal Article
• Authors: Poordast, Tahere; Najib, Fatemeh Sadat; Tanide, Nader; Kanani, Afsoon; Mokhtari, Maral; Chaman-Ara, Kefayat
• Is Part Of: Journal of endometriosis and pelvic pain disorders. Volume 11:Issue 3(2019)
• Page Start: 132
• Page End: 136
• Publication Date: 2019-09
• Subjects: Endometriosis -- induced endometriosis -- triptorelin -- calendula -- rat; Endometriosis -- Periodicals; Pelvic pain -- Periodicals; 618.1
• DOI: 10.1177/2284026519855293
• Languages: English
• ISSNs: 2284-0265

Abstract

Background: Endometriosis is defined as the growth of endometrial glands and stoma extra-uterine sites. It is an estrogen-dependent inflammatory disease estimated to affect 10% of women of reproductive age. This study aimed at comparing the effects of Triptorelin and Calendula officinalis on the induced endometriosis in female rats. Materials and Methods: In this experimental study in an animal model, 52 rats with induced endometriosis were divided into four groups. The control group was treated with 0.5 mL/kg normal saline orally, the second group with single intramuscular injection of Triptorelin S.R.11.25 (3 mg/kg), the third group with Calendula 1000 mg/kg, and the fourth group with Calendula 2000 mg/kg for 6 weeks. The mean area and volume of endometriosis and pathological scores of endometriotic implants were compared between groups. Results: After 6 weeks of treatment, Triptorelin was able to reduce the mean area and volume of endometriotic implants (p < 0.05), but Calendula did not have a significant effect compared to the control group. Mean rank of pathologic score in Triptorelin group had a significant difference with the control group and Calendula 1000 mg/kg (adjusted α < 0.001, adjusted α = 0.004). There was no significant difference in score between the control group and Calendula 1000 mg/kg and 2000 mg/kg. Conclusion: Based on our findings in the used doses, Calendula was not effective for the treatment of experimental endometriosis in rats.