Advances in the treatment of chronic graft‐versus‐host disease. Issue 3 (9th April 2019)

• Record Type: Journal Article
• Authors: Johnson, Eric D.; Couriel, Daniel R.
• Is Part Of: Advances in cell and gene therapy. Volume 2:Issue 3(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-09
• Subjects: bone marrow transplantation -- chronic graft versus host disease -- graft‐versus‐host disease -- survivorship; Cellular therapy -- Periodicals; Gene therapy -- Periodicals; Immunotherapy -- Periodicals; Cancer -- Treatment -- Periodicals; Bone marrow -- Diseases -- Treatment -- Periodicals; Blood -- Diseases -- Treatment -- Periodicals; 615.5
• DOI: 10.1002/acg2.55
• Languages: English
• ISSNs: 2573-8461

Abstract

Abstract: Chronic Graft Versus Host Disease (cGVHD) occurs in over 50‐70% of patients undergoing hematopoietic stem‐cell transplantation (HSCT) and is the leading cause of late non‐relapse mortality. cGVHD typically has insidious multi‐organ involvement and has been associated with a worse quality of life, functional status, and increased risk of subsequent comorbidities. The last several years have seen advances in the understanding of the disease, which provided a framework for the design of translational and clinical studies with newer agents currently at different phases which that may hopefully change the course of the disease. This review provides an overview of more commonly used and newer second line options for the management of cGVHD.