Familial TGCT: polygenic aetiology advanced. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Greene, Mark; Pfeiffer, Ruth
• Is Part Of: Nature reviews. Volume 15:Issue 11(2018)
• Page Start: 665
• Page End: 666
• Publication Date: 2018-11
• Subjects: Urology -- Periodicals; Clinical medicine -- Periodicals; Urology -- Diseases -- Diagnosis -- Periodicals; Urology -- Diseases -- Treatment -- Research -- Periodicals; 616.6005
• DOI: 10.1038/s41585-018-0093-y
• Languages: English
• ISSNs: 1759-4812

Abstract

A polygenic risk score (PRS) analysis reported that familial testicular germ cell tumours (TGCTs) were significantly enriched for TGCT risk alleles and that ≥84% were attributable to polygenic enrichment, supporting the polygenic aetiological basis of familial TGCT. Clinical application will first require improved TGCT screening and early detection tools.