T cells in coeliac disease: a rational target for diagnosis and therapy. Issue 10 (October 2018)

• Record Type: Journal Article
• Authors: Hardy, Melinda; Tye-Din, Jason
• Is Part Of: Nature reviews. Volume 15:Issue 10(2018)
• Page Start: 583
• Page End: 584
• Publication Date: 2018-10
• Subjects: Gastroenterology -- Periodicals; Hepatology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.3005
• DOI: 10.1038/s41575-018-0043-4
• Languages: English
• ISSNs: 1759-5045

Abstract

New findings show that disease-specific T cells that target gluten in patients with coeliac disease persist for decades. The data highlight a central role for a highly select and stable population of T cells in disease persistence and support the feasibility of diagnostics and therapies targeting these cells.