A MEG study of the neural substrates of semantic processing in semantic variant primary progressive aphasia. Issue 3 (4th July 2019)

• Record Type: Journal Article
• Authors: Pineault, Jessica; Jolicœur, Pierre; Grimault, Stephan; Lacombe, Jacinthe; Brambati, Simona Maria; Bier, Nathalie; Chayer, Céline; Joubert, Sven
• Is Part Of: Neurocase. Volume 25:Issue 3/4(2019)
• Page Start: 118
• Page End: 129
• Publication Date: 2019-07-04
• Subjects: Semantic memory -- single-case study -- semantic variant primary progressive aphasia -- functional neuroimaging; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2019.1631853
• Languages: English
• ISSNs: 1355-4794

Abstract

ABSTRACT: Despite a well-documented pattern of semantic impairment, the patterns of brain activation during semantic processing in semantic variant primary progressive aphasia (svPPA) still remain poorly understood. In the current study, one svPPA patient (EC) and six elderly controls carried out a general-level semantic categorization task while their brain activity was recorded using magnetoencephalography (MEG). Despite similar behavioral performance, EC showed hyperactivation of the left inferior temporal gyrus (ITG) and right anterior temporal lobe (ATL) relative to controls. This suggests that periatrophic regions within the ATL region may support preserved semantic abilities in svPPA.