Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress. (19th June 2019)

• Record Type: Journal Article
• Authors: Tucker, Matthew A.; Fox, Brandon M.; Seigler, Nichole; Rodriguez-Miguelez, Paula; Looney, Jacob; Thomas, Jeffrey; McKie, Kathleen T.; Forseen, Caralee; Davison, Gareth W.; Harris, Ryan A.
• Other Names: Pechanova Olga Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2019(2019)
• Publication Date: 2019-06-19
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2019/1629638
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF). Oxidative stress may contribute to vascular dysfunction via inhibition of nitric oxide (NO) bioavailability. Purpose . To determine if ingestion of a single antioxidant cocktail (AOC) improves vascular endothelial function in patients with CF. Methods . In 18 patients with CF (age 8-39 y), brachial artery flow-mediated dilation (FMD) was assessed using a Doppler ultrasound prior to and two hours following either an AOC (n = 18 ; 1, 000 mg vitamin C, 600 IU vitamin E, and 600 mg α -lipoic acid) or a placebo (n = 9 ). In a subgroup of patients (n = 9 ), changes in serum concentrations of α -tocopherol and lipid hydroperoxide (LOOH) were assessed following AOC and placebo. Results . A significant (p = 0.032 ) increase in FMD was observed following AOC (Δ 1.9 ± 3.3 % ), compared to no change following placebo (Δ − 0.8 ± 1.9 % ). Moreover, compared with placebo, AOC prevented the decrease in α -tocopherol (Δ 0.48 ± 2.91 vs.− 1.98 ± 2.32 μ M, p = 0.024 ) and tended to decrease LOOH (Δ − 0.2 ± 0.1 vs.0.1 ± 0.1 μ M, p = 0.063 ). Conclusions . These data demonstrate that ingestion of an antioxidant cocktail can improve vascular endothelial function and improve oxidative stress in patients with CF, providing evidence that oxidative stress is a key contributor to vascular endothelial dysfunction in CF.