Analysis of Clinical Outcome of Patients with Poorly Differentiated Thyroid Carcinoma. (9th March 2011)

• Record Type: Journal Article
• Authors: Tanaka, Katsuhiro; Sonoo, Hiroshi; Saito, Wataru; Ohta, Yusuke; Shimo, Toshiro; Sohda, Mai; Yamamoto, Yutaka; Kurebayashi, Junichi
• Other Names: Cincotta A. H. Academic Editor.
• Is Part Of: ISRN endocrinology. Volume 2011(2011)
• Publication Date: 2011-03-09
• Subjects: Endocrinology -- Periodicals; Endocrine System Diseases; Endocrinology; Endocrinology; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 616.4
• DOI: 10.5402/2011/308029
• Languages: English
• ISSNs: 2090-4630

Abstract

Abstract : Background . We retrospectively analyzed whether poor differentiation is the independent prognostic factor for thyroid carcinoma or not. Methods . The subjects were 29 patients with PDTC who were treated between April 1996 and March 2006 to compare with those of well-differentiated papillary carcinoma patients (n = 227 ). Results . The relapse free (RFS), distant relapse-free survival and cause-specific survival, rates were significantly lower in patients with PDTC (P < .0001, P < .001, andP < .05 ). After classification into focal (<10%) and diffuse type (over 10%) of PDTC, there were no significant differences in RFS and cause-specific survival due to component type or proportion of poorly differentiated component. On multivariate analysis, poor differentiation (P < .0005, RR = 4.456, 95% CI; 1.953–10.167) and extrathyroidal infiltration (P < .05, RR = 2.898, 95% CI; 1.278–6.572) showed a significant impact on DFS, and poor differentiation (P < .05, RR = 9.343, 1.314–66.453) and age (P < .005, RR = 1.306, 1.103–1.547) significantly impacted cause-specific survival. Conclusion . Poor differentiation was an independent factor for survival. Distant relapse was significantly more common among PDTC patients, and systemic therapy might be warranted.