High-Sensitivity C Reactive Protein: Associations with Cardiovascular Risk Factors and Tracking in Female Adolescents and Young Adults. (12th January 2011)

• Record Type: Journal Article
• Authors: Morrison, John A.; Glueck, Charles J.; Daniels, Stephen R.; Wang, Ping; Stroop, Davis M.; Horn, Paul S.
• Other Names: Berkowitz C. D. Academic Editor.; Sarker S. A. Academic Editor.
• Is Part Of: ISRN pediatrics. Volume 2011(2011)
• Publication Date: 2011-01-12
• Subjects: Pediatrics -- Periodicals; Pediatrics; Pediatrics; Periodicals; 618.92
• DOI: 10.5402/2011/707206
• Languages: English
• ISSNs: 2090-469X

Abstract

Abstract : Objective . We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods . Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results . HsCRP did not differ (P > .08 ) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77 ), 16 to 26 (r = 0.50 ), 24 to 26 (r = 0.66 ), and 25 to 26 (r = 0.71 ), allP ≤ .02 . By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24–26 (partialR 2 = 12.3 % P < .0001, 6.6% P = .0012 ). Changes in BMI and triglyceride (partialR 2 = 8.5 % P = .0001, 3.3%, P = .0045 ) were associated with change in hsCRP from age 25 to 26. Conclusions . HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.