Z‐bpy, a New C2‐Symmetric Bipyridine Ligand and Its Application in Enantioselective Copper(I)‐Catalyzed Cyclopropanation of Olefins1. Issue 8 (20th June 2019)

• Record Type: Journal Article
• Authors: Ouyang, Yizhao; Zhan, Miao; Zhou, Jing; Jiao, Jiao; Hu, Hao; Yamada, Yoichi M. A.; Li, Pengfei
• Is Part Of: Chinese journal of chemistry. Volume 37:Issue 8(2019)
• Page Start: 807
• Page End: 810
• Publication Date: 2019-06-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201900141
• Languages: English
• ISSNs: 1001-604X

Abstract

Summary of main observation and conclusion: A rigid C 2 ‐symmetric chiral bipyridine ligand Z‐bpy with a triptycene‐like backbone was designed and synthesized from simple chemicals in a scalable route. Using this new ligand, copper(I) catalyzed cyclopropanation of styrenes with commercial ethyl diazoacetate produced various corresponding cyclopropanes in high yields, diastereoselectivity and enantioselectivity up to 97% ee . Abstract : A new C 2 ‐symmetric bipyridine ligand with triptycene‐like backbone was synthesized and used in highly efficient asymmetric cyclopropanation reaction with small reagent ethyl diazoacetate.