Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy. Issue 7 (10th July 2019)

• Record Type: Journal Article
• Authors: Jakubaszek, Marta; Rossier, Jeremie; Karges, Johannes; Delasoie, Joachim; Goud, Bruno; Gasser, Gilles; Zobi, Fabio
• Is Part Of: Helvetica chimica acta. Volume 102:Issue 7(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-10
• Subjects: bioinorganic chemistry -- cobalamines -- medicinal inorganic chemistry -- photodynamic therapy -- ruthenium polypyridyl complexes; Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201900104
• Languages: English
• ISSNs: 0018-019X

Abstract

Abstract: The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells. Abstract :