Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability. (10th October 2011)

• Record Type: Journal Article
• Authors: Citron, Diane M.; Warren, Yumi A.; Tyrrell, Kerin L.; Goldstein, Ellie J. C.
• Other Names: Ghiringhelli P. D. Academic Editor.
• Is Part Of: ISRN microbiology. Volume 2011(2011)
• Publication Date: 2011-10-10
• Subjects: Microbiology -- Periodicals; Microbiology; Microbiological Phenomena; Fulltext; Internet Resources; Periodicals; 579
• DOI: 10.5402/2011/787290
• Languages: English
• ISSNs: 2090-7478

Abstract

Abstract : Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E. coli, K. pneumoniae, M. catarrhalis, H. influenzae, and streptococci, while an inoculum of 10 6 CFU/mL raised MICs of some E. coli, K. pneumoniae, and M. catarrhalis strains.