Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic neuritis development?. (4th May 2019)

• Record Type: Journal Article
• Authors: Gedvilaite, Greta; Vilkeviciute, Alvita; Kriauciuniene, Loresa; Asmoniene, Virginija; Liutkeviciene, Rasa
• Is Part Of: Ophthalmic genetics. Volume 40:Number 3(2019)
• Page Start: 219
• Page End: 226
• Publication Date: 2019-05-04
• Subjects: Optic neuritis -- CETP -- SIRT1 -- FGFR2 -- STAT3 -- VEGFA -- IL6 -- gene polymorphisms; Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.1080/13816810.2019.1622022
• Languages: English
• ISSNs: 1381-6810

Abstract

ABSTRACT: Objectives : Optic neuritis (ON) is defined as inflammation of the optic nerve, which is mostly idiopathic. However, it can be associated with various causes (demyelinating lesions, autoimmune disorders, infectious and inflammatory conditions). Inflammatory demyelinating disorder of the optic nerve can be associated with multiple sclerosis. It is thought that CETP, SIRT1, FGFR2, STAT3, VEGFA and IL6 genes play a key role in this autoimmune inflammatory disease. The aim of our study was to determine if the frequency of the CETP, SIRT1, FGFR2, STAT3, VEGFA and IL6 gene polymorphisms have an influence on the development of acute ON. Methods : The study enrolled patients with ON and a random sample of healthy population. The genotyping test of the CETPrs5882, rs708272, SIRT1 rs12778366, FGFR2rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms was carried out using the RT-PCR method. Results : Our study determined that the G/A genotype of CETP rs708272 was associated with two-fold-decreased odds of ON development under the codominant (OR = 0.495;95%CI:0.256–0.959) and overdominant (OR = 0.501;95%CI:0.280–0.895) models. Also, each allele C at VEGFA rs833068 was associated with 1.7-fold increased odds of ON development under the additive model (OR = 1.733;95%CI:1.148–2.615). Furthermore, IL6 rs1800795 G/G genotype was associated with increased odds of ON development under the codominant (OR = 2.869;95%CI:1.280–6.434) and recessive (OR = 2.315;95%CI:1.251–4.285) models. Conclusions : We revealed that the genotypes of CETP rs708272 G/A, IL6 rs1800795 G/G, and each allele C at VEGFA rs833068 were associated with ON. CETP rs708272 G/G genotype was associated with decreased by 62% odds of ON with MS development under the recessive (OR = 0.379;95%CI:0.155–0.929; p = .034) model.