Harnessing the reactivity of ortho-formyl-arylketones: base-promoted regiospecific synthesis of functionalized isoquinolines. Issue 57 (27th June 2019)

• Record Type: Journal Article
• Authors: Mishra, Pawan K.; Verma, Shalini; Kumar, Manoj; Kumar, Ankit; Verma, Akhilesh K.
• Is Part Of: Chemical communications. Volume 55:Issue 57(2019)
• Page Start: 8278
• Page End: 8281
• Publication Date: 2019-06-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03689j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines and benzo[ h ] isoquinolines from easily accessible ortho -formyl-arylketones and aryl/(het)arylmethanamines has been described. Abstract : An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines and benzo[ h ] isoquinolines from easily accessible ortho -formyl-arylketones and aryl/(het)arylmethanamines has been described. Challenging 3-alkynyl/alkenyl isoquinolines and bis-isoquinolines were easily attained through this developed chemistry, which can be further used for various organic transformations. Operational simplicity, high atom-economy, broad substrate scope, functional group tolerance and applicability towards large scale synthesis are the advantageous features of this developed methodology.