Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery. Issue 27 (19th June 2019)

• Record Type: Journal Article
• Authors: Hou, Sheng-Lei; Chen, Shuang-Shuang; Huang, Zhang-Jun; Lu, Qing-Hua
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 27(2019)
• Page Start: 4319
• Page End: 4327
• Publication Date: 2019-06-19
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00801b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A drug self-framed delivery system (DSFDS) with dual-stimuli-responsive drug release and superhigh drug loaded capacity for efficient cancer chemotherapy is proposed. Abstract : For clinical applications, simplicity, high efficiency, and low toxicity are key issues in the design of anti-tumor drugs. In this work, a novel dual-responsive drug self-framed delivery system (DSFDS) with high drug delivery efficiency is proposed based on self-framing of an anticancer drug and a tumor-responsive molecule within phosphazene nanoparticles through a simple condensation polymerization method under mild conditions. Due to a unique structural feature of polyphosphazenes, the nanodrug-delivery system showed pH responsiveness. Furthermore, the DSFDS was endowed with glutathione (GSH)-responsiveness by incorporating a cysteine derivative into the polyphosphazene nanoparticles. The dual-responsive DSFDS has been demonstrated to retain high stability during blood circulation and high sensitivity to tumor micromilieu (lower pH in lysosomes and higher GSH concentration in cytoplasm). A super high drug-loading capacity of over 78 wt% made it possible to reduce the usage of the drug and relieve metabolic stress. The proposed DSFDS showed promising potential for highly efficient and controllable release of cancer therapeutics.