Combining antioxidant hydrogels with self-assembled microparticles for multifunctional wound dressings. Issue 27 (20th June 2019)

• Record Type: Journal Article
• Authors: di Luca, Mariagrazia; Curcio, Manuela; Valli, Emanuele; Cirillo, Giuseppe; Voli, Florida; Butini, Maria Eugenia; Farfalla, Annafranca; Pantuso, Elvira; Leggio, Antonella; Nicoletta, Fiore Pasquale; Tavanti, Arianna; Iemma, Francesca; Vittorio, Orazio
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 27(2019)
• Page Start: 4361
• Page End: 4370
• Publication Date: 2019-06-20
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00871c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A multi-functional composite to be employed as a dressing material was prepared by combining hydrogel and microparticle systems. Abstract : A multi-functional composite to be employed as a dressing material was prepared by combining hydrogel and microparticle systems. For the synthesis of the hydrogel counterpart, a free radical polymerization was carried out using a gelatin–curcumin conjugate, previously obtained through immobilized laccase catalysis, and polyethylene glycol dimethacrylate as a functional element, plasticizer, and crosslinker. The hydrogel was found to possess high water affinity, biocompatibility, and the ability to reduce the H2 O2 -induced oxidative stress on MRC-5 cells by 30%. The spherical microparticle system (mean diameter of 1.75 μm) was prepared by self-assembly of a keratin-methacrylated polyethylene glycol-40 stearate derivative synthesized by a free radical reaction. The final composite, prepared by absorption of microparticles on the hydrogel system, was found to be effective as a support for enhanced cell growth (3.5 times). Furthermore, a reduction of methicillin-resistant Staphylococcus aureus proliferation by 1 log10 CFU was reached taking advantage of the sustained release of the antimicrobial quercetin.