A Sc(OTf)3 catalyzed Mukaiyama–Mannich reaction of difluoroenoxysilanes with unactivated ketimines. Issue 14 (6th June 2019)

• Record Type: Journal Article
• Authors: Hu, Xiao-Si; Ding, Pei-Gang; Yu, Jin-Sheng; Zhou, Jian
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 14(2019)
• Page Start: 2500
• Page End: 2505
• Publication Date: 2019-06-06
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00577c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The first example of a Mukaiyama–Mannich reaction of difluoroenoxysilanes with unactivated ketimines catalyzed by Sc(OTf)3 is described. Abstract : An efficient Mukaiyama–Mannich reaction of difluoroenoxysilanes with unactivated ketimines enabled by 5 mol% of Sc(OTf)3 is reported here. This protocol provides expedient access to a series of α, α-difluoro-β-amino ketones possessing a tetrasubstituted carbon center in moderate to high yields (up to 89% yield). Moreover, the Mannich adducts could be easily converted into diversified gem -difluorinated compounds.