Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones. Issue 14 (21st May 2019)

• Record Type: Journal Article
• Authors: Luo, Yi; He, Hua; Li, Jianglian; Yu, Xinling; Guan, Mei; Wu, Yong
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 14(2019)
• Page Start: 2348
• Page End: 2352
• Publication Date: 2019-05-21
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00496c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3 H )-quinazolinones with α-diazotized Meldrum's acid has been achieved successfully via a metal carbene migratory insertion process. Abstract : Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3 H )-quinazolinones with α-diazotized Meldrum's acid has been achieved successfully via a metal carbene migratory insertion process. With a Cp*Rh(iii ) catalyst, monoalkylation compounds are the predominant products while a Cp*Ir(iii ) catalyst selectively affords dialkylation products. Furthermore, these developed methods have good functional group tolerance with a low catalyst loading unprecedentedly.