CuS–MnS2 nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis. Issue 27 (2nd July 2019)

• Record Type: Journal Article
• Authors: Chen, Wancheng; Wang, Xuefei; Zhao, Bingxia; Zhang, Rongjun; Xie, Zhen; He, Yi; Chen, Ali; Xie, Xiaofang; Yao, Kaitai; Zhong, Mei; Yuan, Miaomiao
• Is Part Of: Nanoscale. Volume 11:Issue 27(2019)
• Page Start: 12983
• Page End: 12989
• Publication Date: 2019-07-02
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr03114f
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : With a high incidence and high mortality rate, ovarian cancer presents a challenge for clinical practice. Abstract : With a high incidence and high mortality rate, ovarian cancer presents a challenge for clinical practice. It is thus extremely urgent to investigate new diagnosis and therapy methods for the treatment of ovarian cancer. Ternary copper-based chalcogenide nanomaterials are attractive owing to their near infrared (NIR) response for cancer theranostic fields. However, improving the theranostic efficiency of these nanomaterials is challenging. Herein, CuS–MnS2 nano-flowers were easily synthesized and under NIR irradiation exhibited a relatively high photothermal conversion efficiency of 67.5% and a simultaneous reactive oxygen species (ROS) generation effect. Owing to these outstanding photothermal/photodynamic effects, excellent tumor ablation results could be achieved by the combined use of CuS–MnS2 nano-flowers and 808 nm NIR laser treatments. The main anticancer mechanism of CuS–MnS2 nano-flowers + NIR was likely necroptosis. In addition, the nano-flowers showed remarkable contrast enhancement according to magnetic resonance imaging (MRI). These CuS–MnS2 nano-flowers could thus serve as a promising multifunctional nanotheranostic agent for MRI and as a photothermal/photodynamic cancer therapy agent through necroptosis.