Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides. Issue 14 (3rd June 2019)

• Record Type: Journal Article
• Authors: Arai, Kenta; Osaka, Yuui; Haneda, Masahiro; Sato, Yuumi
• Is Part Of: Catalysis science & technology. Volume 9:Issue 14(2019)
• Page Start: 3647
• Page End: 3655
• Publication Date: 2019-06-03
• Subjects: Catalysis -- Periodicals; 541.395
• DOI: 10.1039/c9cy00562e
• Languages: English
• ISSNs: 2044-4753

Abstract

Abstract : Cyclic tellurides enable rapid and quantitative oxidation of various organothiols through a GPx-like catalytic cycle in a biphasic microflow system. Abstract : Monoamino cyclic tellurides with a five- or six-membered ring structure and their derivatives were developed as a new class of catalyst for the oxidation of organothiols to organodisulfides in a glutathione peroxidase-like catalytic reaction. Quantitative conversion and high reaction rate were achieved by performing the reaction in an organic–aqueous segmented microflow system. Importantly, the process circumvented product purification, which is a major limitation of current organodisulfide synthetic methods.