Copper-catalyzed radical cascade reaction of isocyanate and ethers. Issue 31 (1st August 2019)

• Record Type: Journal Article
• Authors: Wang, Lifeng; Tian, Qingshan; Bin, Chen; Zhang, Guozhu
• Is Part Of: Tetrahedron letters. Volume 60:Issue 31(2019)
• Page Start: 2084
• Page End: 2087
• Publication Date: 2019-08-01
• Subjects: Copper-catalyzed -- Radical reaction -- Amination -- Isocyanate; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.07.013
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Copper-catalyzed amination of ethers. Isocyanate as nitrogen source. DTBP as oxidant and reagent. Radical CH oxidation. Abstract: A novel copper-catalyzed amination of ethers using isocyanates and DTBP is developed. The reaction provides a unique approach to the synthesis of Boc-protected α-aminals through three-component radical cascade reactions. It provides an alternative method for the construction of this type of valuable motifs in high yield. Meanwhile, the method exhibits high tolerance of various functional groups, such as ether, halide, ester and acyl functionalities.