The effect of a novel Bayesian penalised likelihood PET reconstruction algorithm on the assessment of malignancy risk in solitary pulmonary nodules according to the British Thoracic Society guidelines. Issue 117 (August 2019)

• Record Type: Journal Article
• Authors: Murphy, D.J.; Royle, L.; Chalampalakis, Z.; Alves, L.; Martins, N.; Bassett, P.; Breen, R.; Nair, A.; Bille, A.; Chicklore, S.; Cook, G.J.; Subesinghe, M.
• Is Part Of: European journal of radiology. Issue 117(2019)
• Page Start: 149
• Page End: 155
• Publication Date: 2019-08
• Subjects: BPL Bayesian penalised likelihood -- BTS British Thoracic Society -- CT computed tomography -- FDG 2-deoxy-2-[18F]fluoro-D-glucose -- ICC intra-class correlation -- MBP mediastinal blood pool -- OSEM ordered subset expected maximisation -- PET positron emission tomography -- PSF point spread function -- ROC receiver operating characteristic -- SPN solitary pulmonary nodule -- SUV standardised uptake value; Solitary pulmonary nodule -- Fluorodeoxyglucose F18 -- Positron emission tomography computed tomography -- Image reconstruction -- Risk assessment; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.06.005
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Herder score for lung nodule FDG uptake on PET/CT has good inter-reader agreement. Novel BPL PET reconstruction increases the Herder score in 26% of nodules. Herder model diagnostic performance of BPL and standard OSEM PET show no difference. Abstract: Purpose: British Thoracic Society (BTS) guidelines advocate using FDG PET-CT with the Herder model to estimate malignancy risk in solitary pulmonary nodules (SPNs). Qualitative and semi-quantitative assessment of SPN uptake is based upon analysis of Ordered Subset Expected Maximisation (OSEM) PET images. Our aim was to assess the effect of a Bayesian Penalised Likelihood (BPL) PET reconstruction on the assessment of SPN FDG uptake and estimation of malignancy risk (Herder score). Methods: Subjects with SPNs who underwent FDG PET-CT between 2014–2017, with histological confirmation of malignancy or histological/imaging follow-up confirmation of benignity were included. Two blinded readers independently classified SPN uptake on both OSEM and BPL (BTS score; 1 = none; 2 = ≤ mediastinal blood pool (MBP); 3 = >MBP but ≤ 2x liver; 4 = >2x liver), with resultant calculation of the Herder score (%) for both reconstructions. Results: 97 subjects with 75 (77%) malignant SPNs were included. BPL increased the BTS score in 25 (26%) SPNs; 9 SPNs (7 malignant) increased from BTS score 2 to 3, 16 (13 malignant) from BTS score 3 to 4, with a mean Herder score increase of 18 ± 22%. The mean Herder score for all SPNs with BPL was higher than OSEM (73 ± 29 vs 68 ± 32%, p = 0.001). There was no difference in Herder model diagnostic performance between BPL and OSEM, with similar areas under the curve (0.84 vs 0.83, p = 0.39). Conclusion: BPL increases the Herder score in 26% of SPNs compared to OSEM but does not alter the diagnostic performance of the Herder model.