Co-delivery of paclitaxel and melittin by glycopeptide-modified lipodisks for synergistic anti-glioma therapy. Issue 27 (2nd July 2019)

• Record Type: Journal Article
• Authors: Wang, Huan; Wang, Songli; Wang, Ruifeng; Wang, Xiaoyi; Jiang, Kuan; Xie, Cao; Zhan, Changyou; Wang, Hao; Lu, Weiyue
• Is Part Of: Nanoscale. Volume 11:Issue 27(2019)
• Page Start: 13069
• Page End: 13077
• Publication Date: 2019-07-02
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr01820d
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Nanosized lipodisks with flat circular phospholipid bilayers surrounded by PEGylated edges have demonstrated promise in drug delivery. Abstract : Nanosized lipodisks with flat circular phospholipid bilayers surrounded by PEGylated edges have demonstrated promise in drug delivery. In the present work, a lipodisk-based paclitaxel and melittin co-delivery system functionalized with glycopeptide 9 G-A7R ( 9 G-A7R-Disk/PTX/melittin) was successfully constructed, in which melittin which was fully protected from proteolysis and hemolysis was effectively reduced. The ratio of paclitaxel to melittin in lipodisks could be accurately controlled through a film hydration–adsorption method. Paclitaxel combined with melittin showed synergism against U87 cells in vitro, and 9 G-A7R-Disk/PTX/melittin demonstrated an enhanced anti-glioma effect in vivo, significantly prolonging the survival time of glioma-bearing mice. The results suggested a promising formulation for the co-delivery of paclitaxel/melittin and glioma-targeted therapy.