2-Methoxyphenyl isocyanate: a chemoselective multitasking reagent for an amine protection/deprotection sequence. Issue 14 (21st May 2019)

• Record Type: Journal Article
• Authors: Velappan, Anand Babu; Kogatam, Subhashini; Datta, Dhrubajyoti; Srithar, Rakshantha; Nanjappan, Gunasekaran; Debnath, Joy
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 14(2019)
• Page Start: 2360
• Page End: 2364
• Publication Date: 2019-05-21
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00293f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Organic amines protected through urea bond mediated capping. Abstract : Organic amines, in general, are protected through carbamate bond mediated cappings. Herein, we have demonstrated the chemically stable urea linkage suitably employed for protection/deptrotection of amino groups. The stability of the urea linkage under acidic, alkaline and aqueous conditions is an additional advantage for such a protecting group. Therefore the chemoselective nature of 2-methoxyphenyl isocyanate enables its use as a new class of protecting groups which can regenerate free amines after a convenient deprotection step.