Synthesis, Antimicrobial Evaluation, and Docking Studies of Substituted Acetylphenoxymethyl‐triazolyl‐N‐phenylacetamides. (31st May 2019)

• Record Type: Journal Article
• Authors: Phatak, Pramod S.; Sathe, Bhaurao P.; Dhumal, Sambhaji T.; Rehman, Naziya N. M. A.; Dixit, Prashant P.; Khedkar, Vijay M.; Haval, Kishan P.
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 7(2019)
• Page Start: 1928
• Page End: 1938
• Publication Date: 2019-05-31
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3568
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A series of molecules containing acetylphenoxymethyl, triazole, and N ‐phenylacetamide moieties were synthesized via the click chemistry approach. All the synthesized compounds were screened for their antimicrobial activities in vitro . The synthesized compounds8a, 8b, 8m, and8n showed better activities. We further performed exploratory docking studies to gain some insight regarding the molecular mechanism of antibacterial action of these compounds that could guide further structure‐activity relationship (SAR) studies. We examined the interaction of the most active compound with DNA gyrase (pdb id:1KZN). Based on antimicrobial and docking studies, the compounds8a, 8b, 8m, and8n were identified as potential antimicrobial agents. Abstract :