Synthesis, Characterization, and Biological Evaluation of Novel 3‐(4‐Chlorophenyl)‐2‐(substituted)quinazolin‐4(3H)‐one Derivatives as Multi‐target Anti‐inflammatory Agents. (9th June 2019)

• Record Type: Journal Article
• Authors: Raghu, M. S.; Pradeep Kumar, C. B.; Yogesh Kumar, K.; Prashanth, M. K.; Jayanna, B. K.
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 7(2019)
• Page Start: 2046
• Page End: 2051
• Publication Date: 2019-06-09
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3585
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A novel class of 3‐(4‐chlorophenyl)‐2‐(substituted)quinazolin‐4(3 H )‐one derivatives were synthesized, and the structure of synthesized compounds was characterized by IR, 1 H NMR, and mass spectroscopy. The newly synthesized compounds (4a–g and6a–g ) were tested for their in vitro cyclooxygenase (COX) inhibition activity. The compounds have inhibitory profile against both COX‐1 and COX‐2, and some of the compounds are found to be selective against COX‐2. The compound6g showed distinct inhibitory activity on COXs. The synthesized compounds were evaluated for their potential anti‐inflammatory activity as inhibitors of the proinflammatory cytokines IL‐6. Compounds4d –g showed the highest level of inhibition among all the tested compounds. Thus, our data suggested that these compounds may represent a new class of potent anti‐inflammatory agents. Abstract :