Surface modification by deposition of IPA plasma and gellan gum/chitosan hybrid hydrogel onto thermoplastic polyurethane for controlled release of N‐acetylcysteine. Issue 7 (29th April 2019)

• Record Type: Journal Article
• Authors: Pan, Jiunn‐An; Liu, Hsuan‐Liang; Ting, Wei‐Ting; Hsu, Hong‐Kai; Chen, Ko‐Shao
• Is Part Of: Journal of the Chinese Chemical Society. Volume 66:Issue 7(2019)
• Page Start: 691
• Page End: 697
• Publication Date: 2019-04-29
• Subjects: gellan gum/chitosan hybrid hydrogel -- IPA plasma deposition treatment -- thermoplastic polyurethane; Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.201800297
• Languages: English
• ISSNs: 0009-4536

Abstract

Abstract : A thin film system composed of gellan gum and chitosan was fabricated through a combination of polyelectrolyte blend and hybrid hydrogel gelation for controlled release of drug. In this study, precursor isopropyl alcohol (IPA) was used to plasma deposit on the surface of thermoplastic polyurethane (TPU) to form a hydrophilic film. The features of the thin film were evaluated using water contact angle (WCA) measurement, scanning electron microscopy (SEM), Fourier transform infra‐red (FTIR), UV/Vis spectroscopy, and studies of controlled release of drugs. The hybrid hydrogel, pH‐sensitive, was tested at pH values of 1.2 and 7.4 of buffer solution and at a temperature of 37°C to observe its swelling ratio and drug delivery properties with N‐acetylcysteine as a drug material for controlled release. Furthermore, at pH 7.4, the hybrid hydrogel has an outstanding release ratio of up to about 90% absorption amounts of N‐acetylcysteine after 8 hr. The mechanism of drug release from thin film devices ( n = 0.684) is anomalous (non‐Fickian) transport, the value of n lies between 0.43 and 0.85. Abstract : Model PD‐2 bell jar type plasma reactor is a advanced plasma system for material surface modification. Isopropanol was introduced into the surface of TPU improved hydrophilic. Using EDC/NHS for coupling gellan gum/chitosan hybrid hydrogel onto TPU for controlled of N‐acetylcysteine.