The pathogenic actinobacterium Rhodococcus equi: what's in a name?. Issue 1 (17th June 2019)

• Record Type: Journal Article
• Authors: Vázquez‐Boland, José A.; Meijer, Wim G.
• Is Part Of: Molecular microbiology. Volume 112:Issue 1(2019)
• Page Start: 1
• Page End: 15
• Publication Date: 2019-06-17
• Subjects: Molecular microbiology -- Periodicals; 572.829
• DOI: 10.1111/mmi.14267
• Languages: English
• ISSNs: 0950-382X

Abstract

Summary: Rhodococcus equi is the only recognized animal pathogenic species within an extended genus of metabolically versatile Actinobacteria of considerable biotechnological interest. Best known as a horse pathogen, R. equi is commonly isolated from other animal species, particularly pigs and ruminants, and causes severe opportunistic infections in people. As typical in the rhodococci, R. equi niche specialization is extrachromosomally determined, via a conjugative virulence plasmid that promotes intramacrophage survival. Progress in the molecular understanding of R. equi and its recent rise as a novel paradigm of multihost adaptation has been accompanied by an unusual nomenclatural instability, with a confusing succession of names: " Prescottia equi ", " Prescotella equi ", Corynebacterium hoagii and Rhodococcus hoagii . This article reviews current advances in the genomics, biology and virulence of this pathogenic actinobacterium with a unique mechanism of plasmid‐transferable animal host tropism. It also discusses the taxonomic and nomenclatural issues around R. equi in the light of recent phylogenomic evidence that confirms its membership as a bona fide Rhodococcus . Abstract : Vázquez‐Boland and Meijer review the genomics, biology and virulence of Rhodococcus equi, a pathogenic actinobacterium that displays plasmid‐driven animal host tropism. Recent problems regarding the taxonomy and nomenclature of R. equi are also discussed.