Risk scoring system for predicting breast conservation after neoadjuvant chemotherapy. Issue 4 (7th May 2019)

• Record Type: Journal Article
• Authors: Ouldamer, Lobna; Bendifallah, Sofiane; Pilloy, Joseph; Arbion, Flavie; Body, Gilles; Brisson, Caroline; Lavoué, Vincent; Lévêque, Jean; Daraï, Emile
• Is Part Of: Breast journal. Volume 25:Issue 4(2019)
• Page Start: 696
• Page End: 701
• Publication Date: 2019-05-07
• Subjects: breast conservation -- neoadjuvant chemotherapy -- risk scoring system; Breast -- Diseases -- Periodicals; Breast -- Cancer -- Periodicals; 618.19
• DOI: 10.1111/tbj.13303
• Languages: English
• ISSNs: 1075-122X

Abstract

Abstract: We developed a risk scoring system (RSS) for predicting breast conservative surgery (BCS) in women receiving neoadjuvant chemotherapy(NAC) for breast cancer. BCS rate in the training set was 32.6%, associated with five variables: age < 50years, primary radiological tumor diameter < 60mm, absence of multifocality, absence of breast inflammation and hormone receptor status. These variables were assigned scores ranging from 0 to 9. The discrimination of the RSS was 0.78(95%CI 0.69‐0.86) in the training set. The area under the curve of the receiver operating characteristics for predicting BCS after internal and external validation was 0.77(95%CI 0.68‐0.85) and 0.75(95%CI 0.66‐0.84), respectively.