Placentation-related processes in a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) are affected by several xenobiotics. (3rd September 2019)

• Record Type: Journal Article
• Authors: Correia-Branco, Ana; Keating, Elisa; Martel, Fátima
• Is Part Of: Drug and chemical toxicology. Volume 42:Number 5(2019)
• Page Start: 541
• Page End: 545
• Publication Date: 2019-09-03
• Subjects: Extravillous trophoblasts -- HTR-8/SVneo cell line -- proliferation -- viability -- migration -- xenobiotics; Toxicology -- Periodicals; Drugs -- Toxicology -- Periodicals; Toxicology, Experimental -- Periodicals; 615.9005
• DOI: 10.1080/01480545.2018.1463240
• Languages: English
• ISSNs: 0148-0545

Abstract

Abstract: Our aim was to investigate the effect of some xenobiotics on placentation-related processes in an extravillous trophoblastic cell line (HTR-8/SVneo cells). Amphetamine, MDMA, theophylline, and fluoxetine, but not nicotine, cocaine, and caffeine, had a negative effect on cell proliferation rates, culture growth, viability, or migratory capacity. These compounds have a detrimental effect in placentation-related processes of HTR-8/SVneo cells.