Capture and elimination of Staphylococcus aureus based on Langmuir–Blodgett MnO2 nanowire monolayer promotes infected wound healing. Issue 26 (11th June 2019)

• Record Type: Journal Article
• Authors: Chen, Bolei; Ji, Fang; Wang, Chang; Gao, Yue; Zhou, Zhen; Li, Zhi; Cao, Huiming; Hao, Liteng; Liu, Guangliang; Liu, Jingfu; Liang, Yong
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 26(2019)
• Page Start: 4198
• Page End: 4206
• Publication Date: 2019-06-11
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00394k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : An antibacterial membrane, consisting of PDMS and TBBPA coated with a human immunoglobulin G modified MnO2 nanowire monolayer, was applied to capture and eliminate Staphylococcus aureus and promote infected wound healing. Abstract : Infections caused by Staphylococcus aureus ( S. aureus ) have a significant contribution to delayed wound healing, and thus raise a particular public health concern. Controlling the interaction between bacterial and tissue cells is considered as a key factor to affect the critical colonization and spreading invasive infection. Thus, we designed and fabricated a manganese dioxide nanowire monolayer based on the Langmuir–Blodgett method. The nanowire monolayer was functionalized by and transferred onto the surface of a tetrabromobisphenol A (TBBPA)-embedded polydimethylsiloxane (PDMS) membrane. The as-prepared composite membrane could decrease the bacterial invasion by capturing and killing the bacteria on its surface. An average capture efficiency of 90% was observed. 87% of the captured bacteria were killed according to the extended release of TBBPA from the PDMS membrane. The results from in vivo experiments demonstrate that the as-prepared antibacterial membrane could promote the infected wound healing in a mouse model. This IgG-functionalized MnO2 nanowire-coated TBBPA-embedded PDMS membrane appears promising in potential clinical applications against external infections caused by S. aureus .