A modified Pudovik reaction, self-catalysis synthesis of 3-phosphinoylindoles. Issue 30 (25th July 2019) - Liu, Guofeng
Graphical abstract: Highlights: We obtained 3-phosphinoylindoles with a self-catalysis system. Quaternary stereocenters were constructed. Undergo smoothly in mild reaction conditions. 3-phosphinoylindoles were obtained in high yields. Abstract: A new method for the synthesis of organophosphorus compounds between 3-hydroxy-3-indolyloxindoles and phosphite is described here. A modified Pudovik reaction is an efficient way applied in this approach. To be specific, this reaction proceeds smoothly under mild conditions with a self-catalysis system, diversely substituted α-functionalized phosphates are afforded with quaternary stereocenters in high yield, and the reaction time is acceptable due to the high reactivity.