Detection of Brodifacoum and other Rodenticides in Drug Mixtures using Thermal Desorption Direct Analysis in Real Time Mass Spectrometry (TD‐DART‐MS)1. Issue 4 (10th December 2018)

• Record Type: Journal Article
• Authors: Robinson, Elizabeth L.; Sisco, Edward
• Is Part Of: Journal of forensic sciences. Volume 64:Issue 4(2019)
• Page Start: 1026
• Page End: 1033
• Publication Date: 2018-12-10
• Subjects: forensic science -- rodenticides -- DART‐MS -- drug analysis -- brodifacoum -- synthetic cannabinoids -- screening; Medical jurisprudence -- Periodicals; Forensic sciences -- Periodicals; Forensic Medicine -- Periodicals; Gerechtelijke geneeskunde; Gerechtelijke chemie; Gerechtelijke psychiatrie; 363.2505
• DOI: 10.1111/1556-4029.13978
• Languages: English
• ISSNs: 0022-1198

Abstract

Abstract: In recent months, there has been increased reporting of seized drug and toxicology cases containing rodenticides, the active ingredient in rat poisons. Seeing as rodenticides are not scheduled substances, they are not commonly screened for in seized drug analysis. This work investigates the use of TD‐DART‐MS for the simultaneous detection of rodenticides and drugs. Six rodenticides were evaluated, an optimal method was established, and limits of detection in the tens of nanograms were calculated. Additional studies highlight that detection at less than 1% by weight in mixtures with AB‐FUBINACA, cocaine, heroin, or methamphetamine was possible. This work presents an optimized method for detection of these compounds, allowing for the simultaneous detection of drugs and rodenticides, providing drug chemists with a tool for rapid identification of these compounds for forensic or public health purposes.