Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development. Issue 7 (26th April 2019)

• Record Type: Journal Article
• Authors: Friedlander, Edwa; Yirmiya, Nurit; Laiba, Efrat; Harel‐Gadassi, Ayelet; Yaari, Maya; Feldstein, Ohad; Mankuta, David; Israel, Salomon
• Is Part Of: Autism research. Volume 12:Issue 7(2019)
• Page Start: 1087
• Page End: 1100
• Publication Date: 2019-04-26
• Subjects: oxytocin -- oxytocin receptor antagonist -- oxytocin receptor gene -- OXTR -- gene–environment interaction -- autism spectrum disorder; Autism -- Periodicals; Autism -- Research -- Periodicals; 616.85882005
• DOI: 10.1002/aur.2111
• Languages: English
• ISSNs: 1939-3792

Abstract

Abstract : Compelling evidence for the far‐reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor ( OXTR ) gene and risk for autism spectrum disorder (ASD). In the current study, gene–environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty‐three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor ( n = 27); children whose mothers received Nifedipine only to delay preterm labor ( n = 35); children whose mothers received OT for labor augmentation ( n = 56), and a no intervention group ( n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTR risk‐allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTR risk‐allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087–1100 . © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene ( OXTR ). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD‐related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development.