The BEST criteria improve sensitivity for detecting positive cultures in residual blood components cultured in suspected septic transfusion reactions. Issue 7 (23rd April 2019)

• Record Type: Journal Article
• Authors: Shih, Andrew W.; Cohn, Claudia S.; Delaney, Meghan; Fontaine, Magali J.; Martin, Isabella; Dunbar, Nancy M.
• Other Names: Dagger John investigator.; Fadeyi Emmanuel A. investigator.; Flanagan Peter investigator.; Gathof Birgit investigator.; Godbey Elizabeth A. investigator.; Harach Mary investigator.; Huggins Y. Monique investigator.; Ipe Tina S. investigator.; Jackson Bryon investigator.; Jacquot Cyril investigator.; Jin Zhongbo investigator.; Jones Mary Rose investigator.; Kamel Hany investigator.; Karp Julie K. investigator.; Lewin Antoine investigator.; Mo Yunchuan investigator.; Murphy Mike investigator.; O'Brien Jennifer investigator.; Ommer Katharina investigator.; Pagano Monica B. investigator.; Passwater Michael investigator.; Pelletier J. Peter R. investigator.; Robillard Pierre investigator.; Schwartz Joseph investigator.; Sham Lawrence investigator.; Shunkwiler Sara M. investigator.; Simmons Julie S. investigator.; Staves Julie investigator.; Takanaski Minoko investigator.; Vasallo Ralph investigator.; Weiss Susan investigator.; Williams Shelly M. investigator.; Yamada Chisa investigator.; Young Pampee P. investigator.; Ziman Alyssa investigator.;
• Is Part Of: Transfusion. Volume 59:Issue 7(2019)
• Page Start: 2292
• Page End: 2300
• Publication Date: 2019-04-23
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.15317
• Languages: English
• ISSNs: 0041-1132

Abstract

Abstract : BACKGROUND: Culturing residual blood components after suspected septic transfusion reactions guides management of patients and cocomponents. Current practice, accuracy of provider vital sign assessment, and performance of the AABB culture criteria are unknown. A multicenter international study was undertaken to investigate these issues and develop improved culture criteria. STUDY DESIGN AND METHODS: Retrospective data for all transfusion reactions resulting in residual blood component culture in 2016 were collected from participating hospitals. The performance of the AABB culture criteria were assessed for detection of positive culture results. Modifications to the AABB criteria including 1) recommending culturing in the setting of isolated high fevers, 2) defining hypotension and tachycardia using objective parameters, and 3) incorporating antipyretic use were tested to determine if modifications improved performance. Modifications associated with improvement were incorporate into the BEST criteria. The AABB and the BEST criteria were then tested against a data set enriched for positive culture results to determine which criteria were superior. RESULTS: Data were collected from 20 centers encompassing 779, 143 transfusions, 3, 187 reported transfusion reactions, and 1, 104 cultured components. There was marked variation in reaction reporting and culturing rates (0.0%‐100.0%). Of 35 total positive component cultures, only one of 35 (2.9%) had concordant patient cultures; 12 of 34 (35.3%) did not have patient cultures performed. The BEST criteria had better sensitivity for detection of a positive culture result compared to the AABB criteria (74% vs. 41%), although specificity decreased (45% vs. 65%). CONCLUSION: Compared to the AABB criteria, the BEST criteria have improved sensitivity for positive culture detection.