Application of Laser Flare Photometry in the Quantification of Blood–Aqueous Barrier Breakdown after Micro-incision Vitrectomy. (19th May 2019)

• Record Type: Journal Article
• Authors: Agarwal, Aniruddha; Joshi, Deepti; Katoch, Deeksha; Aggarwal, Kanika; Singh, Ramandeep; Gupta, Vishali
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 4(2019)
• Page Start: 651
• Page End: 657
• Publication Date: 2019-05-19
• Subjects: Blood–aqueous barrier -- corticosteroids -- inflammation -- laser flare photometry -- MIVS -- pars plana vitrectomy; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1449867
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : The purpose of the study is to quantify aqueous flare using laser flare photometry (LFM) in patients undergoing 25-G pars plana vitrectomy (PPV) and assess the need for postoperative topical corticosteroid administration . Methods : Prospective evaluation of 50 eyes (50 patients) was performed using LFM until day 30 postoperative. Duration of surgery, indication of PPV, and use of laser and/or cryotherapy were noted. Topical corticosteroids were used if mean LFM values were >50, or if there was anterior chamber fibrin. Results : Mean age of the subjects was 48.62 ± 10.07 years. The preoperative LFM value for 50 subjects was 17.42 ± 25.20. Topical corticosteroids were initiated in only 22 patients. The LFM values of subjects were not different from baseline at 1 month whether or not the subjects received corticosteroids ( p > 0.106). Conclusions : With 25-G PPV, there is minimal breakdown of blood–aqueous barrier. LFM helps in monitoring postoperative inflammation, obviating the need for topical corticosteroids in significant number of patients.