Association of Low Vitamin D Levels with Noninfectious Uveitis and Scleritis. (19th May 2019)

• Record Type: Journal Article
• Authors: Llop, Stephanie M.; Davoudi, Samaneh; Stanwyck, Lynn K.; Sathe, Shaleen; Tom, Lisa; Ahmadi, Tina; Grotting, Lindsay; Papaliodis, George N.; Sobrin, Lucia
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 4(2019)
• Page Start: 602
• Page End: 609
• Publication Date: 2019-05-19
• Subjects: Hypovitaminosis D -- noninfectious uveitis -- scleritis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1434208
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To determine whether an association between Vitamin D and noninfectious ocular inflammation exists. Methods : Retrospective case-control study with 765 patients (333 uveitis cases, 103 scleritis cases, 329 controls). Logistic regression models examined the relationship between hypovitaminosis D and ocular inflammation. Results : The odds of having uveitis were 1.92 times higher for patients with hypovitaminosis D compared to patients with normal Vitamin D levels in the multivariate analysis [odds ratio (OR) = 1.92, 95% Confidence Interval (CI) = 1.36–2.72, p = 2.32 × 10 –4 ]. A secondary analysis demonstrated that the odds of developing uveitis or scleritis were 5% lower and 4% lower, respectively, for every unit increase in Vitamin D level (uveitis: OR = 0.95, 95% CI = 0.94–0.97, p = 9.87 × 10 –6 ; scleritis: OR = 0.96, 95% CI = 0.93–0.99, p = 0.009). Conclusion : Hypovitaminosis D was associated with increased risk of ocular inflammation in this retrospective study.