Antibacterial triterpenoids from the leaves of Ilex hainanensis Merr. Issue 17 (2nd September 2019)

• Record Type: Journal Article
• Authors: Zhao, Wen-Wen; Zan, Ke; Wu, Jing-Yue; Gao, Wei; Yang, Jie; Ba, Yin-Ying; Wu, Xia; Chen, Xiao-Qing
• Is Part Of: Natural product research. Volume 33:Issue 17(2019)
• Page Start: 2435
• Page End: 2439
• Publication Date: 2019-09-02
• Subjects: Ilex hainanensis Merr -- triterpenoids -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1452010
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new triterpenoid (1 ) and seven known analogues (2–8 ) were isolated from the leaves of Ilex hainanensis Merr.. Their structures were established by analysis of their MS, 1D and 2D NMR spectroscopic data and comparison with those in the literature. The antibacterial activity of compounds1–8 were evaluated by determination of minimum inhibitory concentration using twofold microdilution broth method against Streptococcus mutans ATCC 25175 (Gram-positive) and Fusobacterium nucleatum ATCC 10953 (Gram-negative). Compounds3 and5 showed significant antibacterial activity against S. mutans in concentration of 9.7 μg/mL, while showed little antibacterial activity against F. nucleatum . On the contrary, the inhibitory activity of compounds1, 2 and6 against F. nucleatum were higher than them against S. mutans . Abstract :