Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Sakamoto, Yuma; Yamamoto, Takuaki; Sugano, Nobuhiko; Takahashi, Daisuke; Watanabe, Toshiyuki; Atsumi, Takashi; Nakamura, Junichi; Hasegawa, Yukiharu; Akashi, Koichi; Narita, Ichiei; Miyamoto, Takeshi; Takeuchi, Tsutomu; Ikari, Katsunori; Amano, Koichi; Fujie, Atsuhiro; Kubo, Toshikazu; Tada, Yoshifumi; Kaneuji, Ayumi; Nakamura, Hiroaki; Miyamura, Tomoya; Kabata, Tamon; Yamaji, Ken; Okawa, Takahiro; Sudo, Akihiro; Ohzono, Kenji; Tanaka, Yoshiya; Yasunaga, Yuji; Matsuda, Shuichi; Imai, Yuuki; Akiyama, Masato; Kubo, Michiaki; Kamatani, Yoichiro; Iwamoto, Yukihide; Ikegawa, Shiro;
• Is Part Of: Scientific reports. Volume 7:Issue 1(2017)
• Page Start: 1
• Page End: 12
• Publication Date: 2017-12
• Subjects: Natural history -- Research -- Periodicals; Biology -- Research -- Periodicals; Physical sciences -- Research -- Periodicals; Earth sciences -- Research -- Periodicals; Environmental sciences -- Research -- Periodicals; 502.85
• DOI: 10.1038/s41598-017-14778-y
• Languages: English
• ISSNs: 2045-2322

Abstract

Abstract Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60, 000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identifiedLINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.