Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors. Issue 1 (December 2018)

• Record Type: Journal Article
• Authors: Bulatov, Emil; Sayarova, Regina; Mingaleeva, Rimma; Miftakhova, Regina; Gomzikova, Marina; Ignatyev, Yuri; Petukhov, Alexey; Davidovich, Pavel; Rizvanov, Albert; Barlev, Nickolai
• Is Part Of: Cell death discovery. Volume 4:Issue 1(2018)
• Page Start: 1
• Page End: 9
• Publication Date: 2018-12
• Subjects: Cell death -- Periodicals; 571.936
• DOI: 10.1038/s41420-018-0120-z
• Languages: English
• ISSNs: 2058-7716

Abstract

Abstract Medicinal bioinorganic chemistry is a thriving field of drug research for cancer treatment. Transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. We report here the biological evaluation of a novel Isatin-Schiff base derivative and its Cu(II) complex in several tumor cell lines by assessing their effects on cellular metabolism, real-time cell proliferation and induction of apoptosis. Further, the impact of compounds on the p53 protein and expression of its target genes, includingMDM2, p21/CDKN1A, andPUMA was evaluated. Results obtained in this study provide further evidence in support of our prior data suggesting the p53-mediated mechanism of action for Isatin-Schiff base derivatives and their complexes and also shed light on potential use of these compounds for stimulation of apoptosis in breast cancer cells via activation of the pro-apoptoticPUMA gene.