Domino Reactions of Chromone‐3‐carboxylic Acids with Aminoheterocycles: Synthesis of Heteroannulated Pyrido[2, 3‐c]coumarins and their Optical and Biological Activity. Issue 47 (20th December 2017)

• Record Type: Journal Article
• Authors: Miliutina, Mariia; Janke, Julia; Chirkina, Elena; Hassan, Sidra; Ejaz, Syeda Abida; Khan, Shafi Ullah; Iqbal, Jamshed; Friedrich, Aleksej; Lochbrunner, Stefan; Ivanov, Anton; Villinger, Alexander; Lecka, Joanna; Sévigny, Jean; Langer, Peter
• Is Part Of: European journal of organic chemistry. Issue 47(2017)
• Page Start: 7148
• Page End: 7159
• Publication Date: 2017-12-20
• Subjects: Domino reactions -- Fused‐ring systems -- Heterocycles -- Biological activity -- Fluorescence; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201701276
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A series of new heteroannulated pyrido[2, 3‐ c ]coumarins have been prepared by the domino reactions of chromone‐3‐carboxylic acid derivatives with electron‐rich binucleophilic aminoheterocycles. The products contain the core structures of coumarin, pyridine, and an annulated five‐membered heterocyclic system, namely pyrazole, pyrrole, or isoazole. The fluorescence of the products was investigated. The products inhibit ecto‐5′‐nucleotidase (e5′NT) enzymatic activity. Abstract : A variety of new heteroannulated pyrido[2, 3‐ c ]coumarins have been prepared by the domino reactions of chromone‐3‐carboxylic acids with aminoheterocycles