High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus. (November 2018)

• Record Type: Journal Article
• Authors: Asrani, Priyanka; Aly, Ashraf; Jiwani, Amyn; Niebuhr, Bruce; Christenson, Robert; Jain, Sunil
• Is Part Of: Journal of perinatology. Volume 38:Number 11(2018)
• Page Start: 1483
• Page End: 1489
• Publication Date: 2018-11
• Subjects: Perinatology -- Periodicals; 618.32005
• DOI: 10.1038/s41372-018-0192-x
• Languages: English
• ISSNs: 0743-8346

Abstract

Abstract Objective To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum. Study design Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Studentt -test, two proportionz -test, and regression analysis. Results Seventy infants were enrolled. Infants in the hsPDA group had lower gestation and birth weight. Mean hsTnT and NTproBNP levels in the hsPDA group were higher compared to the group without an hsPDA, with levels being 251.54 vs 161.6 pg/ml, p < 0.01 for hsTnT and 18181.02 vs 3149.23 pg/ml, p < 0.001 for NTproBNP. Conclusion HsPDA leads to increased hsTnT and NTproBNP levels in preterm infants without affecting cardiac function.