The ventral pallidum as a critical region for fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male Sprague-Dawley rats. (1st September 2019)

• Record Type: Journal Article
• Authors: Rock, Erin M.; Limebeer, Cheryl L.; Aliasi-Sinai, Lital; Parker, Linda A.
• Is Part Of: Neuropharmacology. Volume 155(2019)
• Page Start: 142
• Page End: 149
• Publication Date: 2019-09-01
• Subjects: PF-3845 -- Ventral pallidum -- FAAH inhibition -- Oleoylethanolamide -- Palmitoylethanolamide -- Peroxisome proliferator-activated receptor alpha; 2-AG -- 2-Arachidonoyl-sn-glycerol -- AEA -- Anandamide -- ANOVA -- Analysis of variance -- CB1 -- Cannabinoid 1 -- CB2 -- Cannabinoid 2 -- CTA -- Conditioned taste avoidance -- FAAH -- Fatty acid amide hydrolase -- FAEs -- Fatty acid ethanolamides -- IIC -- Interoceptive insular cortex -- i.p. -- Intraperitoneal -- LiCl -- Lithium chloride -- MAGL -- Monoacylglycerol lipase -- OEA -- Oleoylethanolamide -- PEA -- Palmitoylethanolamide -- PPARα -- Peroxisome proliferator-activated receptor-α -- SAL -- Saline -- s.c. -- Subcutaneous -- SR -- SR141716A -- TR -- Taste reactivity -- VEH -- Vehicle -- VP -- Ventral pallidum; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2019.05.031
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: Here we investigate the involvement of the ventral pallidum (VP) in the anti-nausea effect of fatty acid amide hydrolase (FAAH) inhibition with PF-3845, and examine the pharmacological mechanism of such an effect. We explored the potential of intra-VP PF-3845 to reduce the establishment of lithium chloride (LiCl)-induced conditioned gaping (a model of acute nausea) in male Sprague-Dawley rats. As well, the role of the cannabinoid 1 (CB1 ) receptors and the peroxisome proliferator-activated receptors-α (PPARα) in the anti-nausea effect of PF-3845 was examined. Finally, the potential of intra-VP GW7647, a PPARα agonist, to reduce acute nausea was also evaluated. Intra-VP PF-3845 dose-dependently reduced acute nausea by a PPARα mechanism (and not a CB1 receptor mechanism). Intra-VP administration of GW7647, similarly attenuated acute nausea. These findings suggest that the anti-nausea action of FAAH inhibition may occur in the VP, and may involve activation of PPARα to suppress acute nausea. Highlights: Intra-ventral pallidum (VP) infusion of the fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduced acute nausea. This effect was mediated by a peroxisome proliferator-activated receptor-α- (PPARα) mechanism. Similarly, intra-VP microinfusion of the PPARα agonist GW7647 attenuated acute nausea. FAAH inhibition's anti-nausea effects may occur in the VP and involve PPARα activation.