The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives. Issue 1 (December 2018)

• Record Type: Journal Article
• Authors: Chen, Yanmei; Shang, Xuefang; Li, Congshu; Xue, Zhenzhen; Chen, Hongli; Wu, Hongwei; Wang, Tianyun
• Is Part Of: Scientific reports. Volume 8:Issue 1(2018)
• Page Start: 1
• Page End: 9
• Publication Date: 2018-12
• Subjects: Natural history -- Research -- Periodicals; Biology -- Research -- Periodicals; Physical sciences -- Research -- Periodicals; Earth sciences -- Research -- Periodicals; Environmental sciences -- Research -- Periodicals; 502.85
• DOI: 10.1038/s41598-018-34331-9
• Languages: English
• ISSNs: 2045-2322

Abstract

Abstract A series of chemsensors (1 –4 ) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H2 S. The advantages of the synthesized fluorescent probe (compound1 ) were the low detection limit (4 × 10−6 mol·L−1 ), good selectivity and high sensitivity which had been demonstrated through UV-vis, fluorescent titration experiments. Besides cytotoxicity test of compounds (1 and2 ) was studied and the results indicated that compounds (1 and2 ) showed almost no cytotoxicityat at a concentration of 150 μg·mL−1 . The interacted mechanism was the thiolysis reaction of dinitrophenyl ether which had been confirmed by fluorescence and HRMS titration experiment. In addition, probe1 can also detect HS− selectively by naked eye in pure DMSO solvent.