(E)-3-(Aryl(arylamino)methylene)indolin-2-one derivatives: an efficient synthetic approach and evaluation of their cancer inhibitory activity. (1st January 2018)

• Record Type: Journal Article
• Authors: Jiang, Hongwu; Feng, Zhiyuan; Chen, Taiping; Li, Zicheng; Huang, Wencai; Luo, Youfu; Zhao, Yinglan
• Is Part Of: Journal of chemical research. Volume 42:Number 1(2018)
• Page Start: 44
• Page End: 49
• Publication Date: 2018-01-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751918X15166485941737
• Languages: English
• ISSNs: 1747-5198

Abstract

A series of (E)-3-(aryl(arylamino)methylene)indolin-2-one derivatives were synthesised using an efficient synthetic approach. The method involved reaction of 3-bromo-3-(bromo(aryl)methyl)indolin-2-one with substituted anilines through nucleophilic substitution and a simultaneous elimination using NaHCO3 in DMF. The anticancer activity of the products against four cell lines, HCT-116, A549, SKOV3 and MDA-MB-231, was also evaluated, and several compounds showed moderate inhibitory activity.