Bioconjugated arylpalladium complexes on solid supports for a convenient last-step synthesis of 11C-labelled tracers for positron emission tomography. Issue 53 (11th June 2019)

• Record Type: Journal Article
• Authors: Tabey, Alexis; Audrain, Hélène; Fouquet, Eric; Hermange, Philippe
• Is Part Of: Chemical communications. Volume 55:Issue 53(2019)
• Page Start: 7587
• Page End: 7590
• Publication Date: 2019-06-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03215k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Bioconjugated arylpalladium complexes anchored onto polystyrene beads provided [ 11 C]CO-labelled compounds with excellent radiochemical purities after a simple filtration. Abstract : Arylpalladium complexes prepared from o -iodobenzylalcohol–biomolecule conjugates and triphenylphosphine linked on polystyrene beads provided convenient supported and stable precursors. These heterogeneous substrates could react smoothly with [ 11 C]CO, affording the corresponding 11 C-labelled bioconjugates with isolated radiochemical yields ranging from 4% to 71%, and excellent radiochemical purities from 86% to >98% after a simple filtration. Thus, this method opens up a new pathway for an easier automation of Pd-catalysed syntheses of PET tracers.